DIRECT CARBON VERSUS PROTON HETERONUCLEAR EDITING OF 2-C-13 ETHANOL IN RABBIT BRAIN INVIVO - A SENSITIVITY COMPARISON

被引：21

作者：

NOVOTNY, EJ

OGINO, T

ROTHMAN, DL

PETROFF, OAC

PRICHARD, JW

SHULMAN, RG

机构：

[1] YALE UNIV, SCH MED, DEPT PEDIAT, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, DEPT INTERNAL MED, NEW HAVEN, CT 06510 USA

[3] YALE UNIV, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 1990年 / 16卷 / 03期

关键词：

D O I：

10.1002/mrm.1910160310

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Proton NMR editing techniques were utilized to study the pharmacology of 13C‐labeled ethanol in the cerebrum of the living rabbit at 4.7 T. The sensitivity of these proton spectroscopic methods was compared to direct carbon spectroscopy and a 14‐fold improvement in sensitivity of 1H over 13C NMR spectroscopy was observed in vivo. This increase in sensitivity permitted the observation of the time course of the influx and afflux of this 13C‐labeled compound with a time resolution of approximately 2 min per spectrum. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

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页码：431 / 443

页数：13

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