HYPERTROPHIC SCAR - A GENETIC HYPOTHESIS

被引：51

作者：

LEWIS, WHP

SUN, KKY

机构：

[1] Department of Health Sciences, Hong Kong Polytechnic, Hung Hom, Kowloon

来源：

BURNS | 1990年 / 16卷 / 03期

关键词：

D O I：

10.1016/0305-4179(90)90033-S

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Two groups of patients with surgical and thermal wounds respectively were tested for aldehyde dehydrogenase 2 deficiency and assessed for the degree of hypertrophy of their scars. No association was found between the deficiency and hypertrophy of the scar. The frequency of hypertrophy was found to be 0.914 in the thermal injury group and 0.446 in the surgical wound group. This difference is statistically significant. The frequency data of the degree of hypertrophy in the two groups has been used to develop and test a single gene hypothesis for the origin of hypertrophy scar in the local Chinese population. It is postulated that the allele responsible for hypertrophy behaves as a dominant allele in the thermal injury group and as a recessive in the surgical wound group for the induction of hypertrophy. © 1990.

引用

页码：176 / 178

页数：3

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