ENHANCEMENT OF INTERLEUKIN-2 ACTIVITY BY LIPOSOMES

被引：20

作者：

JOFFRET, ML

MORGEAUX, S

LECLERC, C

OTH, D

ZANETTI, C

SUREAU, P

PERRIN, P

机构：

[1] INST PASTEUR, UNITE RAGE, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE

[2] INST A FRAPPIER, CTR RECH IMMUNOL, LAVAL, QUEBEC, CANADA

[3] INST PASTEUR, BIOL REGULAT IMMUNITAIRES, F-75724 PARIS 15, FRANCE

来源：

VACCINE | 1990年 / 8卷 / 04期

关键词：

bioassay; Interleukin-2; liposomes; rabies antigens;

D O I：

10.1016/0264-410X(90)90099-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present report demonstrates that liposomes increase the interleukin-2 (IL-2) dependent proliferation of cytotoxic T-lymphocyte line (CTLL) cells used for the measurement of IL-2 activity. This effect was better observed with suboptimal doses of IL-2 and low concentrations of lipids. The increased IL-2 dependent proliferation is not due to a direct effect of liposomes on CTLL cells but rather to an interaction between IL-2 and liposomes. An interaction between IL-2 and components of fetal calf serum is also demonstrated. The results indicate that liposomes may interfere with IL-2 bioassay but also show the possibility of potentiating IL-2 activity for therapeutic purposes. © 1990.

引用

页码：385 / 389

页数：5

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