STUDIES ON THE MECHANISM OF ACTION OF THE ANTIFUNGAL COMPOUND FALCARINDIOL

被引：31

作者：

GARROD, B

LEA, EJA

LEWIS, BG

机构：

[1] School of Biological Sciences, University of East Anglia, Norwich

来源：

NEW PHYTOLOGIST | 1979年 / 83卷 / 02期

关键词：

D O I：

10.1111/j.1469-8137.1979.tb07471.x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The mode of action of the polyacetylenic antifungal compound falcarindiol was explored. Chlamydospores of Mycocentrospora acerina removed falcarindiol from test solutions. Falcarindiol at 28 μg ml−1 burst bimolecular lipid membranes formed from lecithin or lecithin‐cholesterol and caused haemolysis in erythrocytes. At a concentration of 100 μg ml‐1 falcarindiol caused rapid electrolyte loss from both chlamydospores of M. acerina and discs of Doucus carota. Hyphal tips of M. acerina burst, and the internal structure of chlamydospores of M. acerina was altered by concentrations of 75 μg ml‐1 falcarindiol. The hypothesis is advanced that falcarindiol acts on the plasma membrane or affects some process needed for membrane function. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：463 / 471

页数：9

共 17 条

[1] SECOND ANTIFUNGAL POLYACETYLENE COMPOUND FROM PHYTOPHTHORA-INFECTED SAFFLOWER [J].