LONG-ACTING DELIVERY SYSTEMS FOR PEPTIDES - REDUCED PLASMA TESTOSTERONE LEVELS IN MALE-RATS AFTER A SINGLE INJECTION

被引：22

作者：

GASCO, MR ^{[1
]}

PATTARINO, F ^{[1
]}

LATTANZI, F ^{[1
]}

机构：

[1] SCLAVO SPA,SIENA,ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 62卷 / 2-3期

关键词：

Hormone analog; LH-RH; Long-acting delivery; Microemulsion; w/o;

D O I：

10.1016/0378-5173(90)90225-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The study of a biocompatible w/o microemulsion for parenteral administration of peptides was performed. The behaviour of an LH-RH analog, [d-Trp-6]LH-RH, in a w/o microemulsion was evaluated both in vitro and in vivo. After a single intramuscular injection in rats of the microemulsion containing 500 μg/ml of the drug, the plasma levels of testosterone fell; between 10 and 20 days after injection, the plasma testosterone level was lower than that observed after daily injections of 100 μg/kg of the LH-RH analog. The results suggested that prolonged action and protection of biodegradable molecules could be achieved by using w/o microemulsions administered parenterally. © 1990.

引用

页码：119 / 123

页数：5

共 9 条

[1]

CARUNCHIO V, 1984, ANN CHIM-ROME, V74, P331

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