NEPHROTOXICITY IN BONE-MARROW TRANSPLANT RECIPIENTS RECEIVING AMINOGLYCOSIDE PLUS CYCLOSPORINE OR AMINOGLYCOSIDE ALONE

被引：1

作者：

CHANDRASEKAR, PH ^{[1
]}

CRONIN, SM ^{[1
]}

机构：

[1] WAYNE STATE UNIV,HARPER HOSP,DEPT PHARM,DETROIT,MI 48201

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1991年 / 27卷 / 06期

关键词：

D O I：

10.1093/jac/27.6.845

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We performed a retrospective analysis of the medical records of allogeneic bone marrow transplantation (BMT) patients receiving cyclosporine plus an aminoglycoside and autologous BMT patients receiving an aminoglycoside without concurrent cyclosporine in the immediate post-transplant period. Acute nephrotoxicity was not seen in anyof the patients. Concomitantly used agents such as acyclovir, vanco mycin and amphotericin did not worsen renal function. The present study suggests that aminoglycosides, if carefully monitored, can be safely combined with continu ous infusion of cyclosporine without excessive nephrotoxicity. © 1991 The British Society for Antimicrobial Chemotherapy.

引用

页码：845 / 849

页数：5