A SEQUENCE ELEMENT ASSOCIATED WITH THE PLASMODIUM-FALCIPARUM KAHRP GENE IS THE SITE OF DEVELOPMENTALLY REGULATED PROTEIN-DNA INTERACTIONS

被引:51
作者
LANZER, M [1 ]
DEBRUIN, D [1 ]
RAVETCH, JV [1 ]
机构
[1] SLOAN KETTERING MEM CANC CTR, DIV MOLEC BIOL, DEWITT WALLACE RES LAB, 1275 YORK AVE, NEW YORK, NY 10021 USA
关键词
D O I
10.1093/nar/20.12.3051
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Plasmodium falciparum gene encoding the knob associated histidine-rich protein (KAHRP) is shown to be transcriptionally regulated during its expression in the intraerythrocytic cycle as demonstrated by stage specific nuclear run-on analysis. The genomic organization of the KAHRP gene was determined and the structural basis for the stage specific transcription investigated. A sequence motif with two-fold symmetry was found 160 bp upstream of the RNA initiation site. This sequence element interacts with parasite derived nuclear extracts in a stage specific manner that correlates with the transcriptional activity of the KAHRP gene. These studies suggest a functional role for this structural element in the developmental regulation of a P. falciparum erythrocytic gene.
引用
收藏
页码:3051 / 3056
页数:6
相关论文
共 37 条
  • [1] JUNCTIONAL APPARATUS IN ERYTHROCYTES INFECTED WITH MALARIAL PARASITES
    AIKAWA, M
    WELLDE, BT
    RABBEGE, JR
    [J]. ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE, 1972, 124 (01): : 72 - &
  • [2] ORGANIZATION AND EXPRESSION OF THE PLASMODIUM-KNOWLESI CIRCUMSPOROZOITE ANTIGEN GENE
    ALTABA, AR
    OZAKI, LS
    GWADZ, RW
    GODSON, GN
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 23 (03) : 233 - 245
  • [3] BARNWELL JW, 1983, CIBA F SYMP, V94, P117
  • [4] INTERCELLULAR-ADHESION MOLECULE-1 IS AN ENDOTHELIAL-CELL ADHESION RECEPTOR FOR PLASMODIUM-FALCIPARUM
    BERENDT, AR
    SIMMONS, DL
    TANSEY, J
    NEWBOLD, CI
    MARSH, K
    [J]. NATURE, 1989, 341 (6237) : 57 - 59
  • [5] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
  • [6] DNA CLONING OF PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE GENE - AMINO-ACID-SEQUENCE OF REPETITIVE EPITOPE
    ENEA, V
    ELLIS, J
    ZAVALA, F
    ARNOT, DE
    ASAVANICH, A
    MASUDA, A
    QUAKYI, I
    NUSSENZWEIG, RS
    [J]. SCIENCE, 1984, 225 (4662) : 628 - 630
  • [7] THE ESTABLISHMENT OF GENOMIC DNA LIBRARIES FOR THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM AND IDENTIFICATION OF INDIVIDUAL CLONES BY HYBRIDIZATION
    GOMAN, M
    LANGSLEY, G
    HYDE, JE
    YANKOVSKY, NK
    ZOLG, JW
    SCAIFE, JG
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1982, 5 (06) : 391 - 400
  • [8] PROCESSING, POLYMORPHISM, AND BIOLOGICAL SIGNIFICANCE OF P190, A MAJOR SURFACE-ANTIGEN OF THE ERYTHROCYTIC FORMS OF PLASMODIUM-FALCIPARUM
    HALL, R
    OSLAND, A
    HYDE, JE
    SIMMONS, DL
    HOPE, IA
    SCAIFE, JG
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1984, 11 (APR) : 61 - 80
  • [9] PRIMARY STRUCTURE OF THE PRECURSOR TO THE 3 MAJOR SURFACE-ANTIGENS OF PLASMODIUM-FALCIPARUM MEROZOITES
    HOLDER, AA
    LOCKYER, MJ
    ODINK, KG
    SANDHU, JS
    RIVEROSMORENO, V
    NICHOLLS, SC
    HILLMAN, Y
    DAVEY, LS
    TIZARD, MLV
    SCHWARZ, RT
    FREEMAN, RR
    [J]. NATURE, 1985, 317 (6034) : 270 - 273
  • [10] KEMP DJ, 1990, ADV PARASIT, V29, P75