TRIPLE HELIX STRUCTURES - SEQUENCE DEPENDENCE, FLEXIBILITY AND MISMATCH EFFECTS

被引:33
作者
SUN, JS [1 ]
MERGNY, JL [1 ]
LAVERY, R [1 ]
MONTENAYGARESTIER, T [1 ]
HELENE, C [1 ]
机构
[1] INST BIOL PHYS CHIM,BIOCHIM THEOR LAB,CNRS,UA 77,F-75005 PARIS,FRANCE
关键词
D O I
10.1080/07391102.1991.10507925
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
By means of molecular modelling, electrostatic interactions are shown to play an important role in the sequence-dependent structure of triple helices formed by a homopyrimidine oligonucleotide bound to a homopurine. homopyrimidine sequence on DNA. This is caused by the presence of positive charges due to the protonation of cytosines in the Hoogsteen-bonded strand, required in order to form C.GxC+ triplets. Energetic and conformational characteristics of triple helices with different sequences are analyzed and discussed. The effects of duplex mismatches on the triple helix stability are investigated via thermal dissociation using UV absorption.
引用
收藏
页码:411 / 424
页数:14
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