HEPATOCYTE GROWTH-FACTOR ENHANCES B-CELL ACTIVITY

被引：13

作者：

DELANEY, B

KOH, WS

YANG, KH

STROM, SC

KAMINSKI, NE

机构：

[1] KOREA ADV INST SCI & TECHNOL, DEPT LIFE SCI, TAEJON, SOUTH KOREA

[2] VCU, MED COLL VIRGINIA, DEPT PATHOL, RICHMOND, VA USA

[3] MICHIGAN STATE UNIV, DEPT PHARMACOL & TOXICOL, E LANSING, MI 48824 USA

[4] MICHIGAN STATE UNIV, DEPT PATHOL, E LANSING, MI 48824 USA

来源：

LIFE SCIENCES | 1993年 / 53卷 / 05期

关键词：

D O I：

10.1016/0024-3205(93)90654-L

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hepatocyte growth factor (HGF), is one of the growth factors induced and secreted into the serum of partially hepateceomized or hepatotoxin-treated mice that mediates regeneration of hepatic tissue. Results are presented here demonstrating that in addition to hepatotrophic effects, HGF also possesses immunologic activity. In particular, addition of HGF to B6C3F1 mouse spleen cell cultures enhanced humoral immune responses by augmenting the ability of B-cells to secrete immunoglobulin.

引用

页码：PL89 / PL93

页数：5

共 25 条

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