POSSIBLE ANTITUMOR PROMOTERS - BIFLAVONOIDS AND TETRAFLAVONOIDS FROM LOPHIRA-ALATA

被引：30

作者：

MURAKAMI, A

TANAKA, S

OHIGASHI, H

HIROTA, M

IRIE, R

TAKEDA, N

TATEMATSU, A

KOSHIMIZU, K

机构：

[1] SHINSHU UNIV, FAC AGR, DEPT BIOSCI & TECHNOL, KAMI INA, NAGANO 39945, JAPAN

[2] MEIJO UNIV, FAC PHARM, NAGOYA, AICHI 468, JAPAN

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 08期

关键词：

LOPHIRA-ALATA; OCHNACEAE; BARK; ANTITUMOR PROMOTER; BIFLAVONOID; TETRAFLAVONOID;

D O I：

10.1016/0031-9422(92)83612-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three possible flavonoid-type anti-tumour promoters were isolated from the bark of Lophira alata using an in vitro short-term assay, Epstein-Barr virus (EBV) early antigen (EA) induction test. One of the flavonoids was identified as lophirone F. The other two, named azobechalcone A and isolophirachalcone, were a new biflavonoid and a tetraflavonoid, respectively. Azobechalcone A (5-mu-M) and isolophirachalcone (5-mu-M) showed potent inhibitory activities (83% and 65%, respectively) against EBV-EA induction by a tumour promoter, teleocidin B-4 (50 nM). Lophirone F was less active (18% at the same dose) than azobechalcone A and isolophirachalcone.

引用

页码：2689 / 2693

页数：5

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