THE DEVELOPMENT OF GABA(B)-MEDIATED ACTIVITY IN THE RAT DENTATE GYRUS

被引:11
作者
DISCENNA, PG
NOWICKY, AV
TEYLER, TJ
机构
[1] Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272
来源
DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 77卷 / 02期
关键词
GABA(A) RECEPTOR; GRANULE CELL; HIPPOCAMPUS; INHIBITION; PAIRED-PULSE DEPRESSION;
D O I
10.1016/0165-3806(94)90206-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We examined the effects of GABA(B) receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pups. Baclofen (0.25-1.0 mu M), a GABA(B) agonist, rapidly and potently disinhibited the developing dentate, similar to its effect in the mature organism. CGP 35348, a GABA(B) antagonist, quickly reversed the baclofen-induced disinhibition. However, GABA(B) antagonists did not reverse long-latency (500-1000 ms IPI) paired-pulse depression, suggesting that it is not caused by a late GABA(B)-mediated IPSP. GABA(B)-mediated disinhibition of the dentate gyrus can occur by postnatal day 6, providing a powerful mechanism for altering excitability in the developing hippocampus.
引用
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页码:295 / 298
页数:4
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