BEYOND NATURES CHIRAL POOL - ENANTIOSELECTIVE CATALYSIS IN INDUSTRY

被引:211
作者
NUGENT, WA
RAJANBABU, TV
BURK, MJ
机构
关键词
D O I
10.1126/science.259.5094.479
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Enantioselective catalysts produce organic compounds in enantiomerically enriched form. They are highly efficient tools for the synthesis of biologically active materials, such as pharmaceuticals and crop-protection chemicals, in which enantiomeric purity can be critical. The design of chiral ligands is the key to developing new enantioselective catalysts. Three unusual families of ligands have been used to develop practical technology for enantioselective hydrocyanation of olefins, ring-opening of epoxides, and hydrogenation of various compounds.
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页码:479 / 483
页数:5
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