MULTIPLE LOCI AFFECT GENETIC PREDISPOSITION TO HEPATOCARCINOGENESIS IN MICE

被引：94

作者：

MANENTI, G

BINELLI, G

GARIBOLDI, M

CANZIAN, F

DEGREGORIO, L

FALVELLA, FS

DRAGANI, TA

PIEROTTI, MA

机构：

[1] IST NAZL TUMORI,DIV EXPTL ONCOL A,I-20133 MILAN,ITALY

[2] UNIV MILAN,DEPT GENET & MICROBIOL,MILAN,ITALY

来源：

GENOMICS | 1994年 / 23卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1466

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The C3H/He mouse represents a good experimental model of genetic predisposition to hepatocellular tumor development. We analyzed an interspecific testcross population of 106 urethane-treated male (C3H/He x Mus spretus) X C57BL/6J mice, typed with 222 genetic markers to locate precisely the hepatocellular tumor susceptibility (Hcs) loci. Three regions, on chromosomes 2, 5, and 19, showed a significant linkage with hepatocellular tumor development, as indicated by different quantitative indexes estimating liver tumor size. Liver tumor frequency was not genetically controlled. These loci are different from three other Hcs loci that we have previously mapped in an F2 progeny of the C3H/He mouse crossed with the resistant laboratory strain A/J. The present result indicates multigenic model of inheritance for hepatocellular tumor susceptibility. (C) 1994 Academic Press, Inc.

引用

页码：118 / 124

页数：7

共 29 条

[1] GENE TREES AND THE ORIGINS OF INBRED STRAINS OF MICE [J].