INFLUENCE OF POLYMORPHISMS FOR APOLIPOPROTEIN-B (INS/DEL, XBAI, ECORI) AND APOLIPOPROTEIN-E ON SERUM-LIPIDS AND APOLIPOPROTEINS IN A JAVA']JAVANESE POPULATION

A total of 231 healthy subjects from a central Javanese population were investigated for the distribution of three apolipoprotein B (apo B) polymorphisms (ins/del, XbaI, and EcoRI), as well as apolipoprotein E (ape E) polymorphism in relation to serum lipid and apolipoprotein concentrations. The frequencies of the rarer alleles (del, 0.09; X(+), 0.1; and R(-), 0.06) were lower than have been found for some Asian and European populations. Distribution of genotypes was in Hardy-Weinburg equilibrium for all the polymorphisms. A linkage disequilibrium was observed only between the ins/del and XbaI site polymorphisms of apo B (chi(4)(2) = 25.3; P < 0.001) consistent with that observed in some other population studies. No polymorphism of the apo B gene had an association with serum lipid or apolipoprotein concentrations in this population except for XabI, which appeared to be associated with serum TG (as the log transform: R(2) = 8.3; F = 4.8; P < 0.01). The apo E4 allele was found to be associated with significantly higher serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC). Apo E polymorphism explained 5.9% of the sample variance of serum LDLC (F = 5.4; P < 0.01). (C) 1994 Wiley-Liss, Inc.