DEVELOPMENTAL OUTCOME OF PRETERM INFANTS WITH TRANSIENT NEUROMOTOR ABNORMALITIES

Objective.-To determine the relationship between transiently abnormal neurologic findings in preterm infants and subsequent cognitive outcome at 4 years of age. Design.-Prospective 4-year follow-up. Setting.-Regional perinatal center in Syracuse, NY. Participants.-One hundred thirty-one of 135 consecutively born infants of no more than 32 weeks of gestational age; 98% followed up from birth to 4 years of age. Interventions.-None. Measurements and Main Results.-Based on neuromotor evaluations performed at 6 and 15 months of age, two groups of infants were identified. One group had abnormal neurologic findings at 6 months of age that had resolved by 15 months of age (transiently abnormal group). The other group had normal neuromotor findings at both 6 and 15 months of age (normal group). The transiently abnormal group had significantly poorer scores on the Bayley Mental scale at 6 months of age (90+/-15 vs 108+/-10; P<.001), 15 months (91+/-21 vs 105+/-12; P<.001), and 24 months (91+/-19 vs 101+/-17; P<.001). However, at 4 years of age, cognitive performance on the McCarthy Scales was similar for the transiently abnormal 'and normal groups (General Cognitive index, 93+/-13 and 95+/-14, respectively). The incidence of poor cognitive outcome (Cognitive index <84) decreased from 39% at 2 years of age to 18% at 4 years of age in the group with a history of transient neurologic abnormalities but remained unchanged (16% to 18%) in the normal group. Conclusion.-Early neurologic abnormalities that are transient did not predict cognitive delays at 4 years of age in preterm infants.