DETERMINATION OF DNA CROSS-LINKING SEQUENCE SPECIFICITY OF FR66979 - OBSERVATIONS ON THE MODE OF ACTION OF THE FR900482 CLASS OF ANTITUMOR COMPOUNDS

被引：25

作者：

WILLIAMS, RM

RAJSKI, SR

机构：

[1] Department of Chemistry, Colorado State University Fort Collins

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 44期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)61587-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fe(II)-EDTA footprinting of duplex DNA cross-linked by FR-66979, the natural reduction product of FR-900482, reveals that cross-linking proceeds with 5' dCG selectivity. This lends further support to mechanistic proposals which invoke a mitosene intermediate enroute to DNA bis-alkylation.

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页码：7023 / 7026

页数：4

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