CYTOKINE MODULATION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA SECRETION FROM ACUTE MYELOGENOUS LEUKEMIA BLAST CELLS IN-VITRO

被引：22

作者：

BRUSERUD, O

NESTHUS, I

BUHRING, HJ

PAWELEC, G

机构：

[1] HAUKELAND UNIV HOSP,DEPT MED B,DIV HAEMATOL,N-5021 BERGEN,NORWAY

[2] UNIV TUBINGEN,DEPT MED 2,TRANSPLANTAT IMMUNOL & IMMUNOHAEMATOL SECT,TUBINGEN,GERMANY

来源：

LEUKEMIA RESEARCH | 1995年 / 19卷 / 01期

关键词：

ACUTE MYELOGENOUS LEUKEMIA; INTERLEUKIN; 1; TUMOR NECROSIS FACTOR; 3; 4; 6; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE/MACROPHAGE COLONY-STIMULATING FACTOR; STEM CELL FACTOR;

D O I：

10.1016/0145-2126(94)00062-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spontaneous secretion of interleukin 1 (IL-1)alpha, IL-1 beta and tumour necrosis factor-alpha (TNF-alpha) from acute myelogenous leukaemia (AML) blasts showed significant correlation, and detectable levels of all cytokines were seen for a majority of patients. IL-3 and granulocyte/macrophage colony-stimulating factor increased secretion of IL-1 alpha, IL-1 beta and TNF-alpha for a majority of AML patients, whereas IL-4 decreased cytokine secretion. The effect of IL-6 and stem cell factor on cytokine secretion varied between different patients. A wide variation in IL-1 alpha, IL-1 beta and TNF-alpha secretion between different patients was seen both for spontaneous secretion and in the presence of all cytokines.

引用

页码：15 / 22

页数：8

共 23 条

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