IMPORTANCE OF INTERLEUKIN-4 AND INTERLEUKIN-12 IN ALLERGEN-INDUCED AIRWAY CHANGES IN MICE

被引:67
作者
KIPS, JC [1 ]
BRUSSELLE, GG [1 ]
JOOS, GF [1 ]
PELEMAN, RA [1 ]
DEVOS, RR [1 ]
TAVERNIER, JH [1 ]
PAUWELS, RA [1 ]
机构
[1] ROCHE RES GHENT,GHENT,BELGIUM
关键词
ASTHMA; INTERLEUKIN-4; INTERLEUKIN-12; CYTOKINES; MURINE;
D O I
10.1159/000236947
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
T helper 2 (Th2)-like cells are thought to play a crucial role in the pathogenesis of atopic asthma. In this study, we attempted to evaluate the in vivo effect of suppressing Th2 cell development on allergen-induced airway changes. Repeated exposure of actively sensitized C57B1/6 mice to aerosolized ovalbumin (OA) causes, in comparison to saline-exposed control animals, synthesis of specific IgE, increase of eosinophils in bronchoalveolar lavage fluid and airway hyperresponsiveness. These effects are not observed in OA-exposed, sensitized IL-4-knockout mice. Likewise, these effects are inhibited in OA-exposed C57B1/6 mice treated with IL-12 during initial antigen exposure. These results suggest that suppressing Th2 cell development in vivo might have profound inhibitory effects on allergen-induced airway changes.
引用
收藏
页码:115 / 118
页数:4
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