IMPORTANCE OF INTERLEUKIN-4 AND INTERLEUKIN-12 IN ALLERGEN-INDUCED AIRWAY CHANGES IN MICE

被引：67

作者：

KIPS, JC ^{[1
]}

BRUSSELLE, GG ^{[1
]}

JOOS, GF ^{[1
]}

PELEMAN, RA ^{[1
]}

DEVOS, RR ^{[1
]}

TAVERNIER, JH ^{[1
]}

PAUWELS, RA ^{[1
]}

机构：

[1] ROCHE RES GHENT,GHENT,BELGIUM

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

ASTHMA; INTERLEUKIN-4; INTERLEUKIN-12; CYTOKINES; MURINE;

D O I：

10.1159/000236947

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

T helper 2 (Th2)-like cells are thought to play a crucial role in the pathogenesis of atopic asthma. In this study, we attempted to evaluate the in vivo effect of suppressing Th2 cell development on allergen-induced airway changes. Repeated exposure of actively sensitized C57B1/6 mice to aerosolized ovalbumin (OA) causes, in comparison to saline-exposed control animals, synthesis of specific IgE, increase of eosinophils in bronchoalveolar lavage fluid and airway hyperresponsiveness. These effects are not observed in OA-exposed, sensitized IL-4-knockout mice. Likewise, these effects are inhibited in OA-exposed C57B1/6 mice treated with IL-12 during initial antigen exposure. These results suggest that suppressing Th2 cell development in vivo might have profound inhibitory effects on allergen-induced airway changes.

引用

页码：115 / 118

页数：4

共 13 条

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