THE LIM DOMAIN - A NEW STRUCTURAL MOTIF FOUND IN ZINC-FINGER-LIKE PROTEINS

被引：347

作者：

SANCHEZGARCIA, I

RABBITTS, TH

机构：

[1] Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills road

来源：

TRENDS IN GENETICS | 1994年 / 10卷 / 09期

关键词：

D O I：

10.1016/0168-9525(94)90034-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.

引用

页码：315 / 320

页数：6

共 60 条

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