INHIBITION OF CNS MYELIN DEVELOPMENT IN-VIVO BY IMPLANTATION OF ANTI-GALC HYBRIDOMA CELLS

被引：27

作者：

ROSENBLUTH, J ^{[1
]}

LIU, Z ^{[1
]}

GUO, D ^{[1
]}

SCHIFF, R ^{[1
]}

机构：

[1] NYU,SCH MED,DEPT REHABIL MED,NEW YORK,NY 10016

来源：

JOURNAL OF NEUROCYTOLOGY | 1994年 / 23卷 / 11期

关键词：

D O I：

10.1007/BF01181644

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Implantation of hybridoma cells that secrete a monoclonal antigalactocerebroside into the dorsal columns of less than or equal to 9-day-old rat spinal cord results in failure of development of dorsal column myelin in the vicinity of the implant. Clusters of apparently undamaged amyelinated axons remain among the hybridoma cells. Ventral myelin is unaffected. These in vivo results support antibody-mediated inhibition of myelin formation as a potential mechanism underlying failure of remyelination in multiple sclerosis.

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页码：699 / 707

页数：9

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