ISOLATION AND IDENTIFICATION OF A FLUOROPHORE FROM AMPICILLIN DEGRADATION

被引:26
作者
LEBELLE, MJ
VILIM, A
WILSON, WL
机构
[1] Drug Research Laboratories, Health Protection Branch, Health and Welfare Canada, Ottawa, K1A 0L2, Tunney's Pasture
关键词
D O I
10.1111/j.2042-7158.1979.tb13549.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A fluorescent impurity in ampicillin has been isolated and identified as 2‐hydroxy‐3‐phenyl‐pyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis. 1979 Royal Pharmaceutical Society of Great Britain
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页码:441 / 443
页数:3
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