STIMULATION OF PHOSPHOLIPASE-C-GAMMA-1 MEMBRANE ASSOCIATION BY EPIDERMAL GROWTH-FACTOR

被引：153

作者：

TODDERUD, G

WAHL, MI

RHEE, SG

CARPENTER, G

机构：

[1] VANDERBILT UNIV, MED CTR, SCH MED, DEPT BIOCHEM, NASHVILLE, TN 37232 USA

[2] VANDERBILT UNIV, MED CTR, SCH MED, DEPT MED DERMATOL, NASHVILLE, TN 37232 USA

[3] NHLBI, BIOCHEM LAB, BETHESDA, MD 20892 USA

来源：

SCIENCE | 1990年 / 249卷 / 4966期

关键词：

D O I：

10.1126/science.2374928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-γ1 (PLC-γ1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-γ1 suggests that the membrane association of PLC-γ1 is a significant event in second messenger transduction.

引用

页码：296 / 298

页数：3

共 29 条

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