RENAL 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY - EFFECTS OF AGE, SEX AND ALTERED HORMONAL STATUS

被引：27

作者：

SMITH, RE

FUNDER, JW

机构：

[1] Prince Henry's Institute of Medical Research, South Melbourne, 3205 Vic.

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1991年 / 38卷 / 02期

关键词：

D O I：

10.1016/0960-0760(91)90135-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzyme 11-beta-hydroxysteroid dehydrogenase, by converting cortisol and corticosterone to their receptor-inactive 11-keto metabolites cortisone and 11-dehydrocorticosterone, appears crucial to the aldosterone-selectivity of renal mineralocorticoid receptors. Levels of enzyme activity in the rat kidney, measured by conversion of cortisol to cortisone, are unaltered by changes in adrenal or thyroid status, or by castration in either sex; in contrast, oestrogen administration increases enzyme activity in male rats.

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页码：265 / 267

页数：3

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