ORGANOTINS ARE CO-CLASTOGENS IN A WHOLE MAMMALIAN SYSTEM

被引：7

作者：

YAMADA, H ^{[1
]}

SASAKI, YF ^{[1
]}

机构：

[1] KWANSEI GAKUIN UNIV,SCH SCI,BIOL LAB,NISHINOMIYA,HYOGO 662,JAPAN

来源：

MUTATION RESEARCH | 1993年 / 301卷 / 03期

关键词：

ORGANOTINS; MARINE POLLUTANT; COCLASTOGENESIS; MICRONUCLEUS; MITOMYCIN-C;

D O I：

10.1016/0165-7992(93)90078-A

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The frequency of micronuclei induced by mitomycin C (MMC) in mouse peripheral reticulocytes was enhanced by treatment with organotins: bis(tri-n-butyltin) oxide (TBTO) and triphenyltin chloride (TPTC). TBTO and TPTC did not themselves induce micronucleated reticulocytes (MNRETs) in mouse peripheral blood. When 50 mg/kg TBTO or 100 mg/kg TPTC was given orally to mice simultaneously with an intraperitoneal (i.p.) administration of 1 mg/kg MMC, however, TBTO and TPTC caused about 55% and 51% increases, respectively, in MMC-induced a synergistic MNRET frequency. Organotin administration 3 or 6 h before and 3 h after MMC injection also caused enhancement of MNRET frequency. These results demonstrate that TBTO and TPTC act as co-clastogens in a whole mammalian system.

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页码：195 / 200

页数：6

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