INTRASTRIATAL INJECTION OF CHOLINE ACCELERATES THE ACQUISITION OF POSITIVELY REWARDED BEHAVIORS

被引:4
作者
DELGUANTE, MAD
CARBONELLHERNANDEZ, C
QUIRARTE, G
CRUZMORALES, SE
RIVASARANCIBIA, S
PRADOALCALA, RA
机构
[1] UNIV GUADALAJARA, FAC PSICOL, JALISCO, MEXICO
[2] NATL AUTONOMOUS UNIV MEXICO, FAC MED, DEPT FISIOL, MEXICO CITY 04510, DF, MEXICO
[3] UNIV VERACRUZ, CTR ESTUDIOS PSICOL, PSICOFISIOL LAB, JALAPA, VERACRUZ, MEXICO
[4] ENEP IZTACALA, IZTACALA, MEXICO
关键词
STRIATUM; CAUDATE NUCLEUS; ACETYLCHOLINE; CHOLINE; AUTOSHAPING; LEARNING; CONDITIONING;
D O I
10.1016/0361-9230(93)90098-V
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The prediction was made that by increasing the synthesis of striatal acetylcholine, through local injection of its precursor choline, the acquisition of a lever-pressing response in two different autoshaping situations would be accelerated. In the first experiment, choline was injected into the striatum or parietal cortex of rats immediately after dipper training; 24 h later and during 5 consecutive days the animals were submitted to an autoshaping procedure of the operant kind. In the second experiment, choline was administered to the same regions shortly after each of three classical-operant autoshaping sessions; during the next two sessions, autoshaping contingencies of the operant kind were in effect. In both experiments choline injection into the striatum induced a marked facilitation of acquisition of the conditioned responses, although cortical injection of choline produced a milder improvement only in the first experiment. These results indicate that striatal cholinergic activity is, indeed, involved in the early phases of positively reinforced learning.
引用
收藏
页码:671 / 675
页数:5
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