SYNTHESIS OF A STABLE DINUCLEAR COMPLEX FORMED FROM A 26 MEMBERED PROTON-IONIZABLE CROWN OF 3,5-DISUSBSTITUTED 1H-PYRAZOLE AND HOMOVERATRYLAMINE

The 26 membered proton ionizable crown of 3,5-disubstituted 1H-pyrazole 1 acts as a synthetic receptor able to interac with the amino group common to neurotransmitter substrates, such as catecholamines. The synthesis of a solid and stable dinuclear complex formed by proton ionizable crown 1 and homoveratrylamine is described. The FAB mass spectrum of complex, and the differences found in C-13-RMN spectra of crown 1 and its dinuclear complex 3 are commented. The isolation of this dinuclear complex confirm the hypothesis that of synthetic receptor 1 is able to recognise catecholamines and to interact with the amno group of such amines.