BINDING TO DNA AND THE RETINOBLASTOMA GENE-PRODUCT PROMOTED BY COMPLEX-FORMATION OF DIFFERENT E2F FAMILY MEMBERS

被引：241

作者：

KREK, W

LIVINGSTON, DM

SHIRODKAR, S

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

SCIENCE | 1993年 / 262卷 / 5139期

关键词：

D O I：

10.1126/science.8248803

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.

引用

页码：1557 / 1560

页数：4

共 27 条

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