KOJIC ACID, A COSMETIC SKIN WHITENING AGENT, IS A SLOW-BINDING INHIBITOR OF CATECHOLASE ACTIVITY OF TYROSINASE

被引：327

作者：

CABANES, J ^{[1
]}

CHAZARRA, S ^{[1
]}

GARCIACARMONA, F ^{[1
]}

机构：

[1] UNIV MURCIA,FAC VET,DEPT BIOQUIM & BIOL MOLEC A,UNIDAD DOCENTE & BIOL,E-30071 ESPINARDO,SPAIN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 12期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb03253.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It was found that kojic acid, which is used in cosmetics for its excellent whitening effect, inhibits catecholase activity of tyrosinase in a non-classical manner, A decrease in the initial velocity to a steady-state inhibited velocity can be observed over a few minutes. This time-dependence, which is unaltered by prior incubation of the enzyme with the inhibitor, is consistent with a first-order transition. The kinetic data obtained correspond to those for a postulated mechanism that involves the rapid formation of an enzyme inhibitor complex that subsequently undergoes a relatively slow reversible reaction. Kinetic parameters characterizing this type of inhibition were evaluated by means of nonlinear regression of product accumulation curves.

引用

页码：982 / 985

页数：4

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