HIGHLY EFFICIENT ENZYMATIC ASYMMETRIC REDUCTION BY USE OF REGENERATION NADPH IN BAKERS-YEAST CELL-FREE-EXTRACT

被引：16

作者：

ISHIHARA, K ^{[1
]}

SAKAI, T ^{[1
]}

TSUBOI, S ^{[1
]}

UTAKA, M ^{[1
]}

机构：

[1] OKAYAMA UNIV,FAC ENGN,DEPT APPL CHEM,OKAYAMA 700,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)60730-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bakers' yeast cell-free extract was found to reduce 1-acetoxy-2-alkanones to (S)-1-acetoxy-Z-alkanols in 59 - 88% yield and 95 - >99% ee by use of a catalytic amount of NADPH with glucose as a hydride source and without addition of any enzyme for the cofactor regeneration.

引用

页码：4569 / 4570

页数：2

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