MODULATION BY PROSTAGLANDINS OF ACTIVITY OF SLEEP-RELATED NEURONS IN THE PREOPTIC-ANTERIOR HYPOTHALAMIC AREAS IN RATS

被引：25

作者：

KOYAMA, Y ^{[1
]}

HAYAISHI, O ^{[1
]}

机构：

[1] OSAKA BIOSCI INST,SUITA 565,JAPAN

来源：

BRAIN RESEARCH BULLETIN | 1994年 / 33卷 / 04期

关键词：

PREOPTIC AREA; SLOW WAVE SLEEP; WAKEFULNESS; PROSTAGLANDIN D(2); PROSTAGLANDIN E(2); SINGLE NEURONAL ACTIVITY;

D O I：

10.1016/0361-9230(94)90278-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using head-restrained unanesthetized rats, we examined the effects of ionophoretically applied prostaglandin (PG) D2 and PGE2 on the activity of neurons in the preoptic/anterior hypothalamic areas that were classified according to the activity change across sleep-wakefulness cycles. About 24% (84/345) of the neurons had a higher firing rate during slow wave sleep than during wakefulness (S-neurons), and about 14% (47/345) were more active during wakefulness than during slow wave sleep (W-neurons). PGD2 had an excitatory effect on about one-third of the S-neurons examined, while a similar percentage of W-neurons were excited by PGE2. These results suggest that PGD2 and PGE2, influencing sleep-related neurons in the preoptic/anterior hypothalamic areas, are key substances underlying the regulation of sleep and wakefulness.

引用

页码：367 / 372

页数：6

共 39 条

[1]

AVANZINO GL, 1966, J PHARM CHEMOTHER, V27, P157

[2] PROSTAGLANDIN-E LEVELS IN 3RD VENTRICULAR CEREBROSPINAL-FLUID OF RABBITS DURING FEVER AND CHANGES IN BODY-TEMPERATURE [J].