THERMODYNAMIC PROCEDURE TO SYNTHESIZE HETEROPOLYMERS THAT CAN RENATURE TO RECOGNIZE A GIVEN TARGET MOLECULE

被引：85

作者：

PANDE, VS ^{[1
]}

GROSBERG, AY ^{[1
]}

TANAKA, T ^{[1
]}

机构：

[1] MIT,CTR MAT SCI & ENGN,CAMBRIDGE,MA 02139

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 26期

关键词：

RENATURATION; MOLECULAR RECOGNITION;

D O I：

10.1073/pnas.91.26.12976

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an ''active site'' capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

引用

页码：12976 / 12979

页数：4

共 8 条

[1] ARE THERE PATHWAYS FOR PROTEIN FOLDING [J].