STUDIES ON MITOMYCINS .3. SYNTHESIS AND PROPERTIES OF MITOMYCIN DERIVATIVES

被引：46

作者：

MATSUI, M

YAMADA, Y

UZU, K

HIRATA, T

机构：

[1] Department of Agricultural Chemistry, University of Tokyo

来源：

JOURNAL OF ANTIBIOTICS | 1968年 / 21卷 / 03期

关键词：

D O I：

10.7164/antibiotics.21.189

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

About sixty derivatives of mitomycin were synthesized from natural mito-mycins and subjected to antibacterial and antitumor tests. Some of them were more effective than mitomycin C. The structure-activity relationship of derivatives were also investigated. © 1968, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：189 / &

共 9 条

[1] HERR RR, 1961, ANTIMICROBIAL AGENTS, P23
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[3] OBOSHI S, IN PRESS
[4] AZIRIDINOMITOSENES - NEW CLASS OF ANTIBIOTICS RELATED TO MITOMYCINS
PATRICK, JB
FULMOR, W
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[7] STUDIES ON MITOMYCINS CARCINOSTATIC ANTIBIOTICS .1. DERIVATIVES + ACID HYDROLYSIS OF MITOMYCIN A + C
UZU, K
HARADA, Y
WAKAKI, S
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1964, 28 (06): : 388 - &
[8] WEBB JS, 1962, J AM CHEM SOC, V84, P3187, DOI 10.1021/ja00875a033
[9] STRUCTURES OF MITOMYCINS A, B AND C AND PORFIROMYCIN .1.
WEBB, JS
COSULICH, DB
FULMOR, W
MOWAT, JH
BROSCHARD, RW
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WOLFE, CF
PATRICK, JB
MEYER, WE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (16) : 3185 - +

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