STEREOSELECTIVITY OF THE ENANTIOMERS OF TRIHEXYPHENIDYL AND ITS METHIODIDE AT MUSCARINIC RECEPTOR SUBTYPES

被引：42

作者：

LAMBRECHT, G

FEIFEL, R

MOSER, U

AASEN, AJ

WAELBROECK, M

CHRISTOPHE, J

MUTSCHLER, E

机构：

[1] UNIV OSLO,DEPT PHARM,N-0316 OSLO 3,NORWAY

[2] UNIV LIBRE BRUXELLES,SCH MED,DEPT BIOCHEM & NUTR,B-1000 BRUSSELS,BELGIUM

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 155卷 / 1-2期

关键词：

D O I：

10.1016/0014-2999(88)90417-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：167 / 170

页数：4

共 10 条

[1] RELATION BETWEEN BIOLOGICAL-ACTIVITY AND DEGREE OF RESOLUTION OF OPTICAL ISOMERS [J].

BARLOW, RB ;

FRANKS, FM ;

PEARSON, JDM .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1972, 24 (10) :753-&

[2] DIFFERENCES IN STEREOSPECIFICITY OF CLOSELY RELATED COMPOUNDS - REINVESTIGATION OF ENANTIOMERS OF PROCYCLIDINE, BENZHEXOL AND THEIR METHO-SALTS AND ETHO-SALTS [J].

BARLOW, RB .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1971, 23 (02) :90-&

[3] MUSCARINIC M1-RECEPTOR AND M2-RECEPTOR MEDIATING OPPOSITE EFFECTS ON NEUROMUSCULAR-TRANSMISSION IN RABBIT VAS-DEFERENS [J].

ELTZE, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 151 (02) :205-221

[4] BINDING AND FUNCTIONAL PROFILES OF THE SELECTIVE M1 MUSCARINIC RECEPTOR ANTAGONISTS TRIHEXYPHENIDYL AND DICYCLOMINE [J].

GIACHETTI, A ;

GIRALDO, E ;

LADINSKY, H ;

MONTAGNA, E .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (01) :83-90

[5] PARA-FLUORO-HEXAHYDRO-SILA-DIFENIDOL - THE 1ST M2-BETA-SELECTIVE MUSCARINIC ANTAGONIST [J].

LAMBRECHT, G ;

FEIFEL, R ;

FORTH, B ;

STROHMANN, C ;

TACKE, R ;

MUTSCHLER, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 152 (1-2) :193-194

[6]

LAMBRECHT G, 1986, INNOVATIVE APPROACHE, P353

[7] POLYMETHYLENE TETRAMINES - A NEW GENERATION OF SELECTIVE MUSCARINIC ANTAGONISTS [J].

MELCHIORRE, C .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (06) :216-220

[8] ANTIMUSCARINIC ACTION OF METHOCTRAMINE, A NEW CARDIOSELECTIVE M-2 MUSCARINIC RECEPTOR ANTAGONIST, ALONE AND IN COMBINATION WITH ATROPINE AND GALLAMINE [J].

MELCHIORRE, C ;

ANGELI, P ;

LAMBRECHT, G ;

MUTSCHLER, E ;

PICCHIO, MT ;

WESS, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 144 (02) :117-124

[9] SYNTHESES OF (S)-(+)-TRIHEXYPHENIDYL HYDROCHLORIDE AND (S)-(+)-PROCYCLIDINE HYDROCHLORIDE, 2 ANTICHOLINERGICS, USING (S)-(-)-3-CYCLOHEXYL-3-HYDROXY-3-PHENYLPROPANOIC ACID AS CHIRAL SYNTHON [J].

SCHJELDERUP, L ;

HARBITZ, O ;

GROTH, P ;

AASEN, AJ .

ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1987, 41 (05) :356-361

[10] 80-PERCENT OF MUSCARINIC RECEPTORS EXPRESSED BY THE NB-OK 1 HUMAN NEURO-BLASTOMA CELL-LINE SHOW HIGH-AFFINITY FOR PIRENZEPINE AND ARE COMPARABLE TO RAT HIPPOCAMPUS M1 RECEPTORS [J].

WAELBROECK, M ;

CAMUS, J ;

TASTENOY, M ;

CHRISTOPHE, J .

FEBS LETTERS, 1988, 226 (02) :287-290

← 1 →