NEW INSIGHTS IN MOTOR-NEURON DISEASE

被引：11

作者：

MARTIN, JE ^{[1
]}

SWASH, M ^{[1
]}

SCHWARTZ, MS ^{[1
]}

机构：

[1] LONDON HOSP, DEPT NEUROL, LONDON E1 1BB, ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1990年 / 16卷 / 02期

关键词：

Anterior horn; Cytoskeleton; Inclusion body; Motor neuron disease; Neurodegeneration; Ubiquitin;

D O I：

10.1111/j.1365-2990.1990.tb00939.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In motor neuron disease there is a characteristic pattern of nerve cell loss and degeneration of related pathways. In surviving anterior horn cells several morphologically distinct, but generally non-specific, intracytoplasmic inclusion bodies have been recognized. Recently accumulations of previously unrecognized ubiquitinated material have been described in surviving neurons, which cannot be demonstrated with routine histological methods. These changes appear unique to this disease, and provide a new insight into the underlying pathology that may help understand the pathogenesis of this intriguing disorder. In this article we review the new information on the clinical, toxicological and pathological features of the disease.

引用

页码：97 / 110

页数：14

共 73 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].