NEONATAL STRESS AND LONG-TERM MODULATION OF GABA RECEPTORS IN RAT-BRAIN

被引：26

作者：

BOLDEN, SW

HAMBLEY, JW

JOHNSTON, GAR

ROGERS, LJ

机构：

[1] UNIV NEW ENGLAND,DEPT PHYSIOL,ARMIDALE,NSW 2357,AUSTRALIA

[2] UNIV TECHNOL,SCH BIOL & BIOMED SCI,SYDNEY,NSW,AUSTRALIA

[3] UNIV SYDNEY,DEPT PHARMACOL,SYDNEY,NSW 2006,AUSTRALIA

来源：

NEUROSCIENCE LETTERS | 1990年 / 111卷 / 03期

关键词：

Corticosterone; Neonatal handling; Spontaneously hypertensive rat; Stress; Whole brain; γ-Aminobutyric acid binding;

D O I：

10.1016/0304-3940(90)90271-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neonatal handling, known to have long-term effects on behaviour and neuroendocrine responses to acute stress, has been found to produce a long-term change in γ-aminobutyric acid (GABA) receptor binding (Bmax) in whole-brain membranes of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. A significant 10% increase in the binding of [3H] GABA to receptors was evident more than 100 days after handling. There were no differential effects of handling between these two strains, but there was a whole-brain deficit in GABA receptor binding in SHR as compared to WKY animals. Adult corticosterone levels and not correlate with GABA receptor binding. © 1990.

引用

页码：258 / 262

页数：5

共 17 条

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