DECREASED AXONAL FLUX OF RETROGRADELY TRANSPORTED GLYCOPROTEINS IN EARLY EXPERIMENTAL DIABETES

被引：45

作者：

JAKOBSEN, J ^{[1
]}

SIDENIUS, P ^{[1
]}

机构：

[1] AARHUS UNIV,INST ANAT,DEPT CELL BIOL,DK-8000 AARHUS C,DENMARK

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 33卷 / 05期

关键词：

axonal transport; diabetic neuropathies; glycoproteins; streptozotocin diabetes;

D O I：

10.1111/j.1471-4159.1979.tb05241.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Anterograde and retrograde flux of axonal transported glycoproteins were examined in streptozotocin diabetic rats with 4 weeks’duration of the metabolic derangement. [3H]Fucose and [14C]NeuNAc were injected into the fifth lumbar root ganglion and the accumulation of TCA‐PTA insoluble activity proximal and distal to a sciatic nerve ligature was measured. Accumulation of glycoproteins during 2 h collection periods was decreased distal to a ligature in diabetic animals whereas no abnormality of proximal accumulation was observed. These findings demonstrate an abnormality of the retrograde transport of glycoproteins in early experimental diabetes. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1055 / 1060

页数：6

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