EFFECTS OF ACUTE OR CHRONIC ADMINISTRATION OF CHLORDIAZEPOXIDE ON FEEDING PARAMETERS USING 2 FOOD TEXTURES IN THE RAT

被引：29

作者：

COOPER, SJ ^{[1
]}

FRANCIS, RL ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,DEPT PSYCHOL,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 11期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13649.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of acute or chronic administration of chlordiazepoxide on several feeding parameters were studied in the rat. Given acutely, chlordiazepoxide reduced the rate of feeding, at lower dose levels (5·0 or 10·0 mg kg−1) tended to prolong feeding duration, and at a higher dose (15·0 mg kg−1) reduced the amount of food intake. Food texture can influence feeding parameters too; but the effects of the drug did not interact with the effects of food texture. After 9 daily injections of the drug, there were several indications of the development of tolerance to the effects of the drug on the feeding parameters. A possible role of 5‐HT mechanisms in the reduction of eating rate produced by the drug is considered. 1979 Royal Pharmaceutical Society of Great Britain

引用

页码：743 / 746

页数：4

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