ODONTOGENIC-TUMORS IN MICE CARRYING ALBUMIN-MYC AND ALBUMIN-RAS TRANSGENES

被引:17
作者
GIBSON, CW
LALLY, E
HEROLD, RC
DECKER, S
BRINSTER, RL
SANDGREN, EP
机构
[1] UNIV PENN,SCH DENT MED,CRANIOFACIAL ANOMALIES RES CTR,PHILADELPHIA,PA 19104
[2] UNIV PENN,SCH DENT MED,DEPT PATHOL,PHILADELPHIA,PA 19104
[3] UNIV PENN,SCH VET MED,REPROD PHYSIOL LAB,PHILADELPHIA,PA 19104
关键词
ODONTOGENESIS; ONCOGENES; PERIODONTAL LIGAMENT; ALBUMIN; TRANSGENIC MICE;
D O I
10.1007/BF00298506
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Odontogenic tumors that produce abnormal tooth-like structures are repeatedly observed in mandibles of mice that carry both albumin-myc and albumin-ras transgenes. The earliest lesions appear among the periodontal ligament mesenchymal cells, but later lesions include an epithelial component. Subsequent tumor development recapitulates the process of normal tooth formation, which requires multiple sequential cell signals, and results in cell differentiation, matrix secretion, and mineralization. Tumor cells with epithelial morphology produce ras oncoprotein, consistent with an epithelial origin of these tumors. As albumin regulatory sequences direct oncogene expression in these mice, our findings also suggest that some of the albumin present in normal teeth may be locally produced and have a role in tooth mineral formation. The reproducibility of this phenotype makes these mice an excellent model for studies of both normal and neoplastic odontogenesis.
引用
收藏
页码:162 / 167
页数:6
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