AN INCREASED LEVEL OF SPERM ABNORMALITIES IN MICE WITH A PARTIAL DELETION OF THE Y-CHROMOSOME

被引:70
作者
STYRNA, J [1 ]
IMAI, HT [1 ]
MORIWAKI, K [1 ]
机构
[1] NATL INST GENET,DEPT CELL GENET,MISHIMA,SHIZUOKA 411,JAPAN
关键词
D O I
10.1017/S0016672300029268
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Two congenic lines of mice, one with a partial deletion of the Y chromosome, differ in the percentage of spermatozoa with abnormal heads: B10.BR/SgSn males give 22.6% and B10.BR-Y(del)/Ms males give 64.2% abnormal sperm. The F1s resulting from crosses of B10.BR/SgSn males with females of five common inbred strains exhibited significantly lower levels of abnormal sperm than the parental strains, as opposed to F1 hybrids sired by B10.BR-Y(del)/Ms mutant males, where very high levels of abnormal spermatozoa were found. About 30% of abnormal spermatozoa, produced by males with deletion on the Y chromosome, were characterized by a flat acrosomal cap. This class of abnormality was never observed in non-mutant males, suggesting a mutant-specific defect. These results demonstrate the important role of the Y chromosome in spermatogenesis.
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页码:195 / 199
页数:5
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