INFECTIOUS TRANSPLANTATION TOLERANCE

被引：751

作者：

QIN, SX

COBBOLD, SP

POPE, H

ELLIOTT, J

KIOUSSIS, D

DAVIES, J

WALDMANN, H

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND

[2] NATL INST MED RES,MOLEC IMMUNOL LAB,LONDON NW7 1AA,ENGLAND

来源：

SCIENCE | 1993年 / 259卷 / 5097期

关键词：

D O I：

10.1126/science.8094901

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naive lymphocytes so that they too could not reject the graft. The naive lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naive lymphocytes. This process of ''infectious'' tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance.

引用

页码：974 / 977

页数：4

共 15 条

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