ARE SINC AND THE PRP GENE CONGRUENT - EVIDENCE FROM PRP GENE ANALYSIS IN SINC CONGENIC MICE

被引：34

作者：

HUNTER, N ^{[1
]}

DANN, JC ^{[1
]}

BENNETT, AD ^{[1
]}

SOMERVILLE, RA ^{[1
]}

MCCONNELL, I ^{[1
]}

HOPE, J ^{[1
]}

机构：

[1] AFRC,INST ANIM HLTH,COMPTON LAB,NEWBURY RG16 0NN,BERKS,ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-10-2751

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Congenic mouse strains VM/Dk and VM-Sinc(s7)/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sinc(p7p7) and VM-Sinc(s7)/Dk mice are Sinc(s7s7). Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains, confirming the close genetic linkage of Sinc and PrP. Using the restriction enzyme HhaI, we have shown that at least 100 kb of DNA flanking the PrP gene differs between the two strains, and therefore the congruence of the Sinc and PrP genes is still not certain.

引用

页码：2751 / 2755

页数：5

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