IDENTIFICATION OF A SIMPLE TANDEM REPEAT DNA POLYMORPHISM IN THE HUMAN GLYCOGEN-SYNTHASE GENE AND LINKAGE TO 5 MARKERS ON CHROMOSOME-19Q

被引：15

作者：

VIONNET, N

BELL, GI

机构：

[1] HOWARD HUGHES MED INST,5841 S MARYLAND AVE,MC 1028,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

来源：

DIABETES | 1993年 / 42卷 / 06期

关键词：

D O I：

10.2337/diabetes.42.6.930

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have identified a simple tandem repeat DNA polymorphism in the human glycogen synthase gene of the form (TG)n. This DNA polymorphism has 10 alleles and a heterozygosity of 0.82 and can be easily typed using the polymerase chain reaction. It has been localized within the framework genetic map of chromosome 19 and is located in the region of the apolipoprotein C-II and histidine-rich calcium-binding protein genes. This DNA polymorphism will facilitate genetic studies of the role of the glycogen synthase gene in the development of insulin resistance and NIDDM.

引用

页码：930 / 932

页数：3

共 11 条

[1] HUMAN-MUSCLE GLYCOGEN-SYNTHASE CDNA SEQUENCE - A NEGATIVELY CHARGED PROTEIN WITH AN ASYMMETRIC CHARGE-DISTRIBUTION
BROWNER, MF
NAKANO, K
BANG, AG
FLETTERICK, RJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) : 1443 - 1447
[2] ALLELE FREQUENCY-DISTRIBUTION OF THE (TG)N(AG)M MICROSATELLITE IN THE APOLIPOPROTEIN C-II GENE
FORNAGE, M
CHAN, L
SIEST, G
BOERWINKLE, E
[J]. GENOMICS, 1992, 12 (01) : 63 - 68
[3] ASSOCIATION BETWEEN POLYMORPHISM OF THE GLYCOGEN-SYNTHASE GENE AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS
GROOP, LC
KANKURI, M
SCHALINJANTTI, C
EKSTRAND, A
NIKULAIJAS, P
WIDEN, E
KUISMANEN, E
ERIKSSON, J
FRANSSILAKALLUNKI, A
SALORANTA, C
KOSKIMIES, S
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (01) : 10 - 14
[4] PCR-SSCP - A METHOD FOR DETECTION OF MUTATIONS
HAYASHI, K
[J]. GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 1992, 9 (03): : 73 - 79
[5] LATHROP GM, 1985, AM J HUM GENET, V37, P482
[6] ASSIGNMENT OF THE GENE ENCODING GLYCOGEN-SYNTHASE (GYS) TO HUMAN CHROMOSOME-19, BAND-Q13.3
LEHTO, M
STOFFEL, M
GROOP, L
ESPINOSA, R
LEBEAU, M
BELL, GI
[J]. GENOMICS, 1993, 15 (02) : 460 - 461
[7] NISHI S, 1992, DIABETOLOGIA, V35, P743
[8] ROPERS JD, 1991, CYTOGENET CELL GENET, V58, P751
[9] Sambrook J., 1989, MOL CLONING LAB MANU
[10] IMPAIRED ACTIVATION OF GLYCOGEN-SYNTHASE IN PEOPLE AT INCREASED RISK FOR DEVELOPING NIDDM
SCHALINJANTTI, C
HARKONEN, M
GROOP, LC
[J]. DIABETES, 1992, 41 (05) : 598 - 604

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