NUCLEOTIDE-SEQUENCE OF A CDNA FROM ONCHOCERCA-GIBSONI ENCODING A NOVEL REPETITIVE ANTIGEN

被引：5

作者：

CATMULL, J ^{[1
]}

DAN, Z ^{[1
]}

MILLER, DJ ^{[1
]}

机构：

[1] JAMES COOK UNIV N QUEENSLAND,DEPT CHEM & BIOCHEM,TOWNSVILLE,QLD 4811,AUSTRALIA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1992年 / 22卷 / 05期

关键词：

ONCHOCERCA-GIBSONI; CDNA LIBRARY; MICROFILARIAE; ANTIGEN GENES; REPETITIVE SEQUENCES;

D O I：

10.1016/0020-7519(92)90021-C

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

mRNA from uterine microfilariae of the cattle parasite Onchocerca gibsoni was used for the construction of cDNA libraries. A cDNA clone encoding an antigen recognized by serum from human individuals infected with O. volvulus was found to contain five copies of an 87 bp unit. These 87 bp units were present in the genome in high copy number as long tandem arrays. These are the first cDNA sequence data obtained directly from larvae of any Onchocerca species.

引用

页码：685 / 687

页数：3

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