NEW BIOSENSOR USING SHEAR HORIZONTAL SURFACE-ACOUSTIC-WAVE DEVICE

被引：37

作者：

KONDOH, J ^{[1
]}

MATSUI, Y ^{[1
]}

SHIOKAWA, S ^{[1
]}

机构：

[1] SHIZUOKA UNIV,FAC ENGN,DEPT OPTOELECTR & MECH ENGN,HAMAMATSU,SHIZUOKA 432,JAPAN

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS | 1993年 / 32卷 / 5B期

关键词：

SH-SAW SENSOR; BIOSENSOR; ENZYME-IMMOBILIZED SAW SENSOR; ACOUSTOELECTRIC INTERACTION; PH CHANGE MONITORING;

D O I：

10.1143/JJAP.32.2376

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

This paper describes a new biosensor to detect an enzyme reaction in liquid using surface acoustic wave (SAW) devices fabricated on 36-degrees-rotated Y-cut, X-propagating LiTaO3. The sensing wave on the substrate is a predominantly shear-horizontal-mode SAW (SH-SAW) and is affected by a strong acoustoelectric interaction between the piezoelectric potential and electrical properties of the materials in the adjacent liquid. As an example of an electrical property, pH change associated with an enzyme reaction leads to measurable perturbation in the wave-propagation characteristic. Taking advantage of this phenomenon we realized a SAW biosensor which consists of an immobilized urease membrane on the surface. Also, highly sensitive detection for the urea solution was obtained in our preliminary experiments.

引用

页码：2376 / 2379

页数：4

共 12 条

[1] AN ACOUSTIC PLATE MODE BIOSENSOR [J].

ANDLE, JC ;

VETELINO, JF ;

LADE, MW ;

MCALLISTER, DJ .

SENSORS AND ACTUATORS B-CHEMICAL, 1992, 8 (02) :191-198

[2] NEW METHODS FOR BINDING ENZYME MOLECULES INTO A WATER-INSOLUBLE MATRIX - PROPERTIES AFTER INSOLUBILIZATION [J].

BROUN, G ;

THOMAS, D ;

GELLF, G ;

DOMURADO, D ;

BERJONNE.AM ;

GUILLON, C .

BIOTECHNOLOGY AND BIOENGINEERING, 1973, 15 (02) :359-375

[3]

CAMPBELL JJ, 1970, IEEE T SON ULTRASON, V13, P71

[4]

CRITCHLEY M, 1978, MED DICT

[5] ON THE USE OF ZX-LINBO3 ACOUSTIC PLATE MODE DEVICES AS DETECTORS FOR DILUTE ELECTROLYTES [J].

JOSSE, F ;

SHANA, ZA ;

HAWORTH, DT ;

LIEW, S ;

GRUNZE, M .

SENSORS AND ACTUATORS B-CHEMICAL, 1992, 9 (02) :97-112

[6]

Kondoh J., 1992, Transactions of the Institute of Electronics, Information and Communication Engineers C-II, VJ75C-II, P224

[7]

KONDOH J, 1992, 4TH INT M CHEM SENS, P498

[8]

KONDOH J, 1992, JPN J APPL PHYS S311, V31, P31

[9] CHARACTERIZATION OF SH ACOUSTIC PLATE MODE LIQUID SENSORS [J].

MARTIN, SJ ;

RICCO, AJ ;

NIEMCZYK, TM ;

FRYE, GC .

SENSORS AND ACTUATORS, 1989, 20 (03) :253-268

[10]

MORIIZUMI T, 1987, P IEEE ULTR S, P579

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