MODULATION BY DIVALENT-CATIONS OF THE CURRENT GENERATED BY VASOPRESSIN IN FACIAL MOTONEURONS

被引：20

作者：

ALBERI, S ^{[1
]}

DUBOISDAUPHIN, M ^{[1
]}

DREIFUSS, JJ ^{[1
]}

RAGGENBASS, M ^{[1
]}

机构：

[1] UNIV GENEVA,MED CTR,DEPT PHYSIOL,9 AVE CHAMPEL,CH-1211 GENEVA 4,SWITZERLAND

来源：

BRAIN RESEARCH | 1993年 / 624卷 / 1-2期

关键词：

AMPA; BRAIN-STEM SLICE; CALCIUM; CNQX; MAGNESIUM; NEUROPEPTIDE; VOLTAGE-CLAMP;

D O I：

10.1016/0006-8993(93)90097-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vasopressin generates a voltage-gated, sodium-dependent current in facial motoneurons in brainstem slices. Reducing the extracellular calcium concentration from 2 to 0.01 mM caused a 30 to 120% increase in the amplitude of this current. Lowering extracellular magnesium also enhanced it, but less efficiently. In the physiological solution, the response of facial neurons to vasopressin is thus partially blocked. Increasing extracellular calcium was without effect. Current-voltage curves indicate that the vasopressin current reversed at around 0 mV and suggest that the low-calcium-induced potentiation was due to an attenuation of the region of negative slope conductance.

引用

页码：326 / 330

页数：5

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