SYNTHESIS AND BIOLOGICAL-ACTIVITY OF J-104,118, A NOVEL, POTENT INHIBITOR OF SQUALENE SYNTHASE

被引：15

作者：

IWASAWA, Y

HAYASHI, M

NOMOTO, T

SHIBATA, J

MITSUYA, M

HIROTA, K

YONEMOTO, M

KAMEI, T

MIURA, K

TOMIMOTO, K

机构：

[1] Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Tsukuba, 300-33

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 17期

关键词：

D O I：

10.1016/0960-894X(95)00339-U

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new structural class of squalene synthase (SQS) inhibitor, J-104,118, was developed by chemical modification of L-592,901, The absolute configuration of J-104,118 was determined by X-ray crystal analysis. An oral dose of J-104,118 potently inhibited cholesterol synthesis in mice.

引用

页码：1989 / 1994

页数：6

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