CUTANEOUS T-CELL LYMPHOMA DIAGNOSED BY FINE-NEEDLE ASPIRATION - A CASE-REPORT WITH CLINICAL, CYTOLOGICAL, AND IMMUNOPHENOTYPIC FEATURES

被引:4
作者
BASU, D [1 ]
KUMAR, S [1 ]
SHOME, DK [1 ]
CHAUHAN, S [1 ]
机构
[1] MAULANA AZAD MED COLL,DEPT PATHOL,NEW DELHI,INDIA
关键词
MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHADENOPATHY; IMMUNOCYTOCHEMISTRY; T-CELL SUBSETS;
D O I
10.1002/dc.2840110213
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
A case study of cutaneous T-cell lymphoma in a 40-yr-old Indian male is presented. Prominent clinical features consisted of large skin tumours, lymphadenopathy, and a rapidly progressive course of development. Aspiration smears from tumours, lymph nodes, and bone marrow showed pleomorphic Sezary cells and lymphoid blasts. The neoplastic cells stained positively with anti-HLA DR, CD1, and CD2 antibodies and showed lack of T-cell subset antigens CD4 and CD8. Numerous proliferating cells were identified with 56% of bone marrow cells and 57% of cells in the dermis staining positively with Ki-67 and PC10 antibodies, respectively. This case is reported in view of its uncommon features. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:174 / 177
页数:4
相关论文
共 22 条
[1]  
Broder S, Bunn PA, Cutaneous T cell lymphomas, Semin Oncol, 7, pp. 310-331, (1980)
[2]  
Winkelmann RK, Clinical studies of T‐cell erythroderma in the Sezary syndrome, Mayo Clin Proc, 49, pp. 519-525, (1974)
[3]  
Winkelmann RK, Caro WA, Current problems in mycosis fungoides and Sezary syndrome, Ann Rev Med, 28, pp. 251-269, (1977)
[4]  
Lutzner M, Edelson R, Schein P, Green I, Kirkpatrick C, Ahmed A., Cutaneous T‐cell lymphomas. The Sezary syndrome, mycosis fungoides and related disorders, Ann Int Med, 83, pp. 534-552, (1975)
[5]  
Glendenning WE, Brecker G, Van Scott EJ, Mycosis fungoides, Arch Dermatol, 87, pp. 785-792, (1964)
[6]  
Rappaport H, Thomas LB, Mycosis fungoides. The pathology of extracutaneous involvement, Cancer, 34, pp. 1198-1229, (1978)
[7]  
Variakojis D, Rosas-Uribe A, Rappaport H., Mycosis fungoides. Pathologic findings in staging laparotomies, Cancer, 33, pp. 1589-1600, (1974)
[8]  
Winkelmann RK, Hoagland HC, The Sezary cell in the blood of patients with mycosis fungoides, Dermatologica, 160, pp. 73-79, (1980)
[9]  
Huehner E, Wantzin GL, Mason DY, Hou-Jensen K, Stein H, Thomsen K., Phenotypic characterization of lymphocyte subsets in mycosis fungoides, Am J Clin Pathol, 84, pp. 610-619, (1985)
[10]  
Wood GS, Abel EA, Hoppe RT, Warnke RA, Leu‐8 and Leu‐9 antigen phenotypes. Immunologic criteria for the distinction of mycosis fungoides from cutaneous inflammation, J Am Acad Dermatol, 14, pp. 1006-1013, (1986)