Morphine Taste Conditioning and Analgesia: Assessing Conditioned and Novelty-Induced Analgesia

被引：4

作者：

Bevins, Rick A. ^{[1
]}

Valone, Joanne M. ^{[1
]}

Bradley, Melinda C. ^{[1
]}

Bardo, Michael T. ^{[1
]}

机构：

[1] Univ Kentucky, Dept Psychol, Kastle Hall, Lexington, KY 40506 USA

来源：

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY | 1995年 / 3卷 / 01期

关键词：

D O I：

10.1037/1064-1297.3.1.9

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

In previous work showing a taste-elicited decrease in pain sensitivity (J. S. Miller, K. S. Kelly, J. L. Neisewander, D. F. McCoy, & M. T. Bardo, 1990), the rats (Rattus norvegicus) were always habituated to an inactive hot plate after each drug injection. The present report examined whether the analgesic response was a conditioned response to the taste or a response to the novelty of the hot plate resulting from morphine disrupting the habituation process. In 3 experiments, it was found that hot plate novelty was mainly responsible for the analgesic response. For example, increasing the number of conditioning trials did not enhance analgesia in morphine-treated rats. Rather, it attenuated analgesia in saline-treated controls (habituation). Also, rats given habituation in a drug-free state failed to show an analgesic response compared with controls.

引用

页码：9 / 14

页数：6

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