ANALYSIS OF RAT AMYLIN AMIDE FROM COMMERCIAL SOURCES - IDENTIFICATION OF A MERCURY COMPLEX

被引：6

作者：

CODY, WL ^{[1
]}

GIORDANI, AB ^{[1
]}

WERNESS, S ^{[1
]}

REILY, MD ^{[1
]}

BRISTOL, JA ^{[1
]}

ZHU, GC ^{[1
]}

DUDLEY, DT ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES DIV,DEPT SIGNAL TRANSDUCT,ANN ARBOR,MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80268-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analysis of four commercial samples of rat amylin amide by HPLC, CZE and biological activity showed one sample (A) was different from the other three (B, C and D). Additional structural analysis of sample A (Edman sequencing, amino acid analysis, H-1 NMR and FAB-MS) suggested it was indeed rat amylin amide. However, electrospray ionization mass spectrometry and scanning electron microscopy showed sample A contained mercury covalently bound to the side chains of the cysteines in positions 2 and 7.

引用

页码：415 / 420

页数：6

共 20 条

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