DETERMINATION OF THE BETA-ANOMERIC CONFIGURATION OF CYTIDINE 5'-MONOPHOSPHO-N-ACETYLNEURAMINIC ACID BY C-13 NMR-SPECTROSCOPY

被引：82

作者：

HAVERKAMP, J

SPOORMAKER, T

DORLAND, L

VLIEGENTHART, JFG

SCHAUER, R

机构：

[1] UNIV UTRECHT,ORGAN CHEM LAB,NL-3522 AD UTRECHT,NETHERLANDS

[2] UNIV KIEL,INST BIOCHEM,D-2300 KIEL 1,FED REP GER

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1979年 / 101卷 / 17期

关键词：

D O I：

10.1021/ja00511a012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The anomeric configuration of the NeuAc residue in enzymically prepared cytidine 5ʹ-monophospho-N'-acetylneuraminic acid was established to be β on the basis of the heteronuclear vicinal coupling constant 3J-H3ax. For comparison the 3JCL -H3 values of a number of α and β N-acetylneuraminic acid derivatives have also been determined. The biochemical implication of this finding is discussed. © 1979, American Chemical Society. All rights reserved.

引用

页码：4851 / 4853

页数：3

共 26 条

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